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Holdings, Q2 2026

Largest first. Common shares only; puts and calls are under All positions.

Latest 13F holdings
#The fund's own figures at the end of the quarter. A report can be up to 45 days old when it is filed. Options and bonds are not counted here.Filing
1GH
Guardant Health, Inc.
3.39M$509.1M7.4%+1.6%13F ↗
2IMVT
Immunovant, Inc.
9.34M$359.9M5.2%-19.0%13F ↗
3GPCR
Structure Therapeutics Inc.
4.74M$254.4M3.7%+10.8%13F ↗
4PCVX
Vaxcyte, Inc.
4.30M$250.0M3.6%Unchanged13F ↗
5ALNY
Alnylam Pharmaceuticals, Inc.
825,000$248.3M3.6%New13F ↗
6MANE
Veradermics, Incorporated
2.00M$245.9M3.6%+300%13F ↗
7TARS
Tarsus Pharmaceuticals, Inc.
3.67M$230.8M3.4%+1.9%13F ↗
8Nuvalent Inc1.78M$220.2M3.2%+29.6%13F ↗
9ALKS
Alkermes plc
4.00M$209.6M3.1%+11.4%13F ↗
10OCUL
Ocular Therapeutix, Inc.
19.69M$193.3M2.8%Unchanged13F ↗
11BMRN
BioMarin Pharmaceutical Inc.
3.31M$189.3M2.8%+188%13F ↗
12NRIX
Nurix Therapeutics, Inc.
7.74M$187.7M2.7%+21.9%13F ↗
13ORKA
Oruka Therapeutics, Inc.
1.93M$183.3M2.7%-5.3%13F ↗
14ALMS
Alumis Inc.
6.35M$178.6M2.6%-6.3%13F ↗
15IONS
Ionis Pharmaceuticals, Inc.
2.20M$174.4M2.5%+12.8%13F ↗
16CMPS
COMPASS Pathways Plc · ADR
12.16M$172.1M2.5%Unchanged13F ↗
17VERA
Vera Therapeutics, Inc.
4.00M$171.6M2.5%-2.6%13F ↗
18AXSM
Axsome Therapeutics, Inc.
700,000$171.3M2.5%-36.4%13F ↗
19GMAB
Genmab A/S · ADR
5.65M$155.2M2.3%+54.2%13F ↗
20MLTX
MoonLake Immunotherapeutics
7.00M$136.3M2.0%+9.2%13F ↗
21COAG
Hemab Therapeutics Holdings, Inc.
3.60M$132.3M1.9%New13F ↗
22TNGX
Tango Therapeutics, Inc.
4.20M$131.3M1.9%+52.7%13F ↗
23DFTX
Definium Therapeutics, Inc.
2.75M$129.4M1.9%-8.3%13F ↗
24GRAL
GRAIL, Inc.
1.83M$125.3M1.8%+6.5%13F ↗
25BCAX
Bicara Therapeutics Inc.
4.10M$121.7M1.8%+0.9%13F ↗
26MAZE
Maze Therapeutics, Inc.
3.73M$111.4M1.6%+7.3%13F ↗
27CLDX
Celldex Therapeutics, Inc.
2.94M$109.4M1.6%+129%13F ↗
28LBRX
LB Pharmaceuticals Inc
3.35M$108.8M1.6%Unchanged13F ↗
29MBX
MBX Biosciences, Inc.
1.73M$95.6M1.4%-37.2%13F ↗
30GHRS
GH Research PLC
3.33M$89.6M1.3%New13F ↗
31COGT
Cogent Biosciences, Inc.
2.00M$77.4M1.1%+100%13F ↗
32Ataibeckley Inc14.42M$76.0M1.1%+20.1%13F ↗
33UTHR
United Therapeutics Corporation
123,616$67.0M1.0%New13F ↗
34AVTX
Avalo Therapeutics, Inc.
3.61M$66.7M1.0%New13F ↗
35VRDN
Viridian Therapeutics, Inc.
3.59M$66.0M1.0%+158%13F ↗
36CYTK
Cytokinetics, Incorporated
700,000$59.6M0.9%-49.1%13F ↗
37ALT
Altimmune, Inc.
19.25M$58.5M0.9%New13F ↗
38PSNL
Personalis, Inc.
4.00M$53.6M0.8%+33.3%13F ↗
39ACRS
Aclaris Therapeutics, Inc.
9.35M$49.4M0.7%Unchanged13F ↗
40CRMD
CorMedix Inc.
6.27M$49.3M0.7%Unchanged13F ↗
41WGS
GeneDx Holdings Corp.
700,000$48.1M0.7%New13F ↗
42HROW
Harrow, Inc.
969,000$41.2M0.6%New13F ↗
43CRVS
Corvus Pharmaceuticals, Inc.
2.49M$37.2M0.5%Unchanged13F ↗
44SLDB
Solid Biosciences Inc.
3.57M$35.6M0.5%Unchanged13F ↗
45BEAM
Beam Therapeutics Inc.
1.00M$34.3M0.5%+21.8%13F ↗
46DYN
Dyne Therapeutics, Inc.
1.50M$33.3M0.5%-25.0%13F ↗
47IMMX
Immix Biopharma, Inc.
2.77M$28.6M0.4%New13F ↗
48XFOR
X4 Pharmaceuticals, Inc.
5.88M$27.5M0.4%-7.3%13F ↗
49STTK
Shattuck Labs, Inc.
3.71M$25.7M0.4%New13F ↗
50MNKD
MannKind Corporation
6.00M$25.6M0.4%New13F ↗

Changes since Q1 2026

18 new, 22 added to, 15 trimmed, 14 exited, 11 unchanged. By estimated dollars.

New positions (18)

New positions
ALNY
Alnylam Pharmaceuticals, Inc.
825,000New$248.3M
COAG
Hemab Therapeutics Holdings, Inc.
3.60MNew$132.3M
GHRS
GH Research PLC
3.33MNew$89.6M
UTHR
United Therapeutics Corporation
123,616New$67.0M
AVTX
Avalo Therapeutics, Inc.
3.61MNew$66.7M
ALT
Altimmune, Inc.
19.25MNew$58.5M
WGS
GeneDx Holdings Corp.
700,000New$48.1M
HROW
Harrow, Inc.
969,000New$41.2M
IMMX
Immix Biopharma, Inc.
2.77MNew$28.6M
STTK
Shattuck Labs, Inc.
3.71MNew$25.7M

Added to (22)

Added to
MANE
Veradermics, Incorporated
2.00M+300%$184.4M
BMRN
BioMarin Pharmaceutical Inc.
3.31M+188%$123.5M
CLDX
Celldex Therapeutics, Inc.
2.94M+129%$61.6M
GMAB
Genmab A/S · ADR
5.65M+54.2%$54.6M
Nuvalent Inc1.78M+29.6%$50.3M
TNGX
Tango Therapeutics, Inc.
4.20M+52.7%$45.3M
VRDN
Viridian Therapeutics, Inc.
3.59M+158%$40.4M
COGT
Cogent Biosciences, Inc.
2.00M+100%$38.7M
NRIX
Nurix Therapeutics, Inc.
7.74M+21.9%$33.8M
GPCR
Structure Therapeutics Inc.
4.74M+10.8%$24.7M

Trimmed (15)

Trimmed
AXSM
Axsome Therapeutics, Inc.
700,000-36.4%-$97.9M
IMVT
Immunovant, Inc.
9.34M-19.0%-$84.2M
CYTK
Cytokinetics, Incorporated
700,000-49.1%-$57.4M
MBX
MBX Biosciences, Inc.
1.73M-37.2%-$56.6M
IMCR
Immunocore Holdings plc · ADR
311,218-83.9%-$51.5M
ALMS
Alumis Inc.
6.35M-6.3%-$11.9M
DFTX
Definium Therapeutics, Inc.
2.75M-8.3%-$11.8M
DYN
Dyne Therapeutics, Inc.
1.50M-25.0%-$11.1M
ORKA
Oruka Therapeutics, Inc.
1.93M-5.3%-$10.3M
ENTA
Enanta Pharmaceuticals, Inc.
1.44M-26.2%-$7.5M

Exited (14)

Exited
Apellis Pharmaceuticals Inc4.53MExited-$182.3M
Centessa Pharmaceuticals plc
ADR
3.16MExited-$125.4M
BBIO
BridgeBio Pharma, Inc.
841,445Exited-$62.5M
Terns Pharmaceuticals Inc1.07MExited-$56.6M
GERN
Geron Corporation
31.72MExited-$47.3M
ANIP
ANI Pharmaceuticals, Inc.
600,000Exited-$46.1M
Soleno Therapeutics Inc1.08MExited-$36.1M
Engene Holdings Inc4.38MExited-$29.8M
Apogee Therapeutics Inc285,000Exited-$24.0M
JANX
Janux Therapeutics, Inc.
1.19MExited-$16.5M

The 10 largest of each, by estimated dollars: shares changed times the later report's price. Index tracking, splits and mergers move positions too.

All positions

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Compare two quarters

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Reported value by quarter

Value and number of positions at the end of each quarter.

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Largest positions in earlier quarters

Pick a quarter to see what the fund's biggest positions were then.

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Ten largest positions

By value, Q2 2026.

$0$200.0M$400.0M$600.0MGH · Value: $509,098,599GHIMVT · Value: $359,914,548IMVTGPCR · Value: $254,399,664GPCRPCVX · Value: $249,959,000PCVXALNY · Value: $248,349,750ALNYMANE · Value: $245,880,000MANETARS · Value: $230,786,378TARSNuvalent… · Value: $220,240,267Nuvalent…ALKS · Value: $209,580,000ALKSOCUL · Value: $193,319,289OCUL

Filings

13F filings
Filing
Q2 2026Aug 14, 202613F-HR67$6.9BCurrentSEC ↗
Q1 2026May 15, 202613F-HR63$6.1BCurrentSEC ↗
Q4 2025Feb 13, 202613F-HR55$5.6BCurrentSEC ↗
Q3 2025Nov 14, 202513F-HR56$3.6BCurrentSEC ↗
Q2 2025Aug 14, 202513F-HR66$3.1BCurrentSEC ↗
Q1 2025May 15, 202513F-HR69$3.1BCurrentSEC ↗

Most recent first, up to 80. An amendment can replace a report or add holdings to it. All 13F filings

Information, not investment advice. Values are the fund's own figures at quarter end; a report can be up to 45 days old when filed. Disclaimer