Insider trades › Opaleye Management Inc.
Opaleye Management Inc.
A corporate insider: an officer, director or owner of more than 10% of a company. Insiders report their trades to the SEC on Form 4The form insiders use to report each purchase or sale of their company's stock. It is due within two business days of the trade. · Last filing Nov 5, 2026
Companies
7
where this person reports as an insider
Open-market buys
82
among the latest 100 trades
Open-market sales
18
among the latest 100 trades
Ask your AI about this
Connect Claude, ChatGPT, Gemini or Grok (Microsoft 365 Copilot coming soon) to 13F.ai and ask in plain English. Copy a question to get started:
Using 13F.ai, list Opaleye Management Inc.'s open-market buys and sells across companies in the last two years, with the Form 4 links.
Using 13F.ai, how did the stocks Opaleye Management Inc. bought perform after the purchase compared with the S&P 500?
Using 13F.ai, are other insiders at the same companies buying or selling at the same time as Opaleye Management Inc.?
Connect your AI · Plans and the 7-day free trial (card required)
Buying and selling by quarter
Dollars bought and sold on the open market over the last two years.
Bought Sold
By trade date, using the shares and price reported for each trade. Stock grants, option exercises and shares withheld for tax are left out.
Roles
The companies where this person reports as an insider, and their position at each, most recent first.
| GRCE Grace Therapeutics, Inc. | 10% owner | Nov 5, 2026 |
| ACOG Alpha Cognition Inc. | 10% owner | Oct 26, 2026 |
| SLGL Sol-Gel Technologies Ltd. | 10% owner | Sep 14, 2026 |
| ETON Eton Pharmaceuticals, Inc. | 10% owner | Jul 17, 2026 |
| SNWV SANUWAVE Health, Inc. | 10% owner | May 4, 2026 |
| HROW Harrow, Inc. | 10% owner | Mar 5, 2026 |
| CDXS Codexis, Inc. | 10% owner | Dec 15, 2025 |
Roles come from the filings themselves and can change over time.
Latest open-market trades
Purchases and sales at every company, most recent filing first.
| How the stock has done since the trade date, measured against the S&P 500 over the same days. It describes the stock, not the trader's actual gain or loss. | Filing | ||||||
|---|---|---|---|---|---|---|---|
| Nov 5, 2026 | GRCE Grace Therapeutics, Inc. | Buy | 3,087 | $1.77 | $5,478 | -1.2% | Form 4 ↗ |
| Nov 4, 2026 | GRCE Grace Therapeutics, Inc. | Buy | 5,027 | $1.80 | $9,060 | +1.6% | Form 4 ↗ |
| Nov 3, 2026 | GRCE Grace Therapeutics, Inc. | Buy | 10,328 | $1.79 | $18.5K | -1.6% | Form 4 ↗ |
| Oct 26, 2026 | GRCE Grace Therapeutics, Inc. | Buy | 66,411 | $1.77 | $117.4K | +1.4% | Form 4 ↗ |
| Oct 23, 2026 | ACOG Alpha Cognition Inc. | Buy | 14,973 | $8.23 | $123.3K | +0.3% | Form 4 ↗ |
| Oct 22, 2026 | GRCE Grace Therapeutics, Inc. | Buy | 21,390 | $1.93 | $41.2K | -4.2% | Form 4 ↗ |
| Oct 22, 2026 | ACOG Alpha Cognition Inc. | Buy | 17,117 | $8.33 | $142.5K | +1.1% | Form 4 ↗ |
| Oct 19, 2026 | GRCE Grace Therapeutics, Inc. | Buy | 4,256 | $1.88 | $8,001 | -2.1% | Form 4 ↗ |
| Oct 16, 2026 | ACOG Alpha Cognition Inc. | Buy | 14,283 | $8.23 | $117.6K | +2.5% | Form 4 ↗ |
| Oct 15, 2026 | ACOG Alpha Cognition Inc. | Buy | 22,657 | $8.43 | $191.0K | +0.5% | Form 4 ↗ |
| Oct 16, 2026 | GRCE Grace Therapeutics, Inc. | Buy | 36,347 | $1.89 | $68.8K | -3.1% | Form 4 ↗ |
| Oct 15, 2026 | GRCE Grace Therapeutics, Inc. | Buy | 23,485 | $1.95 | $45.7K | -4.9% | Form 4 ↗ |
| Oct 14, 2026 | GRCE Grace Therapeutics, Inc. | Buy | 11,233 | $1.93 | $21.7K | -2.3% | Form 4 ↗ |
| Sep 25, 2026 | ACOG Alpha Cognition Inc. | Buy | 13,426 | $8.47 | $113.7K | +0.2% | Form 4 ↗ |
| Sep 24, 2026 | ACOG Alpha Cognition Inc. | Buy | 18,337 | $8.57 | $157.1K | -1.5% | Form 4 ↗ |
| Sep 23, 2026 | GRCE Grace Therapeutics, Inc. | Buy | 5,318 | $2.10 | $11.2K | -12.9% | Form 4 ↗ |
| Sep 21, 2026 | GRCE Grace Therapeutics, Inc. | Buy | 9,771 | $2.10 | $20.5K | -11.3% | Form 4 ↗ |
| Sep 16, 2026 | ACOG Alpha Cognition Inc. | Buy | 53,029 | $8.57 | $454.5K | -1.2% | Form 4 ↗ |
| Sep 16, 2026 | ACOG Alpha Cognition Inc. | Buy | 27,141 | $8.40 | $228.0K | -1.2% | Form 4 ↗ |
| Sep 15, 2026 | ACOG Alpha Cognition Inc. | Buy | 3,375 | $8.54 | $28.8K | -5.3% | Form 4 ↗ |
| Sep 14, 2026 | ACOG Alpha Cognition Inc. | Buy | 40,373 | $8.70 | $351.2K | -3.9% | Form 4 ↗ |
| Sep 11, 2026 | SLGL Sol-Gel Technologies Ltd. | Buy | 1,493 | $65.95 | $98.5K | -15.1% | Form 4 ↗ |
| Sep 10, 2026 | SLGL Sol-Gel Technologies Ltd. | Buy | 1,631 | $66.80 | $109.0K | -17.0% | Form 4 ↗ |
| Sep 9, 2026 | GRCE Grace Therapeutics, Inc. | Buy | 5,836 | $2.09 | $12.2K | -14.4% | Form 4 ↗ |
| Sep 8, 2026 | GRCE Grace Therapeutics, Inc. | Buy | 9,393 | $2.10 | $19.7K | -13.1% | Form 4 ↗ |
| Sep 9, 2026 | SLGL Sol-Gel Technologies Ltd. | Buy | 3,097 | $68.71 | $212.8K | -19.3% | Form 4 ↗ |
| Sep 8, 2026 | SLGL Sol-Gel Technologies Ltd. | Buy | 471 | $69.37 | $32.7K | -19.0% | Form 4 ↗ |
| Sep 8, 2026 | SLGL Sol-Gel Technologies Ltd. | Buy | 3,390 | $68.74 | $233.0K | -19.0% | Form 4 ↗ |
| Sep 4, 2026 | SLGL Sol-Gel Technologies Ltd. | Buy | 2,100 | $68.98 | $144.9K | -18.7% | Form 4 ↗ |
| Sep 4, 2026 | SLGL Sol-Gel Technologies Ltd. | Buy | 918 | $69.52 | $63.8K | -18.7% | Form 4 ↗ |
| Sep 2, 2026 | SLGL Sol-Gel Technologies Ltd. | Buy | 900 | $68.95 | $62.1K | -20.3% | Form 4 ↗ |
| Sep 1, 2026 | SLGL Sol-Gel Technologies Ltd. | Buy | 783 | $69.52 | $54.4K | -19.7% | Form 4 ↗ |
| Aug 31, 2026 | SLGL Sol-Gel Technologies Ltd. | Buy | 5,000 | $68.24 | $341.2K | -18.6% | Form 4 ↗ |
| Aug 31, 2026 | SLGL Sol-Gel Technologies Ltd. | Buy | 217 | $69.10 | $15.0K | -18.6% | Form 4 ↗ |
| Aug 28, 2026 | SLGL Sol-Gel Technologies Ltd. | Buy | 5,000 | $68.81 | $344.1K | -17.9% | Form 4 ↗ |
| Aug 28, 2026 | SLGL Sol-Gel Technologies Ltd. | Buy | 10,000 | $71.40 | $714.0K | -17.9% | Form 4 ↗ |
| Aug 28, 2026 | SLGL Sol-Gel Technologies Ltd. | Buy | 20,113 | $68.42 | $1.4M | -17.9% | Form 4 ↗ |
| Aug 14, 2026 | GRCE Grace Therapeutics, Inc. | Buy | 11,608 | $2.09 | $24.3K | -13.4% | Form 4 ↗ |
| Aug 12, 2026 | SLGL Sol-Gel Technologies Ltd. | Buy | 951 | $71.50 | $68.0K | -20.6% | Form 4 ↗ |
| Aug 3, 2026 | ACOG Alpha Cognition Inc. | Buy | 50,000 | $8.00 | $400.0K | -1.1% | Form 4 ↗ |
| Jul 31, 2026 | ACOG Alpha Cognition Inc. | Buy | 2,900 | $7.92 | $23.0K | -0.7% | Form 4 ↗ |
| Jul 24, 2026 | ACOG Alpha Cognition Inc. | Buy | 130 | $7.90 | $1,027 | +3.0% | Form 4 ↗ |
| Jul 23, 2026 | ACOG Alpha Cognition Inc. | Buy | 49,849 | $7.80 | $388.8K | -1.3% | Form 4 ↗ |
| Jul 22, 2026 | ACOG Alpha Cognition Inc. | Buy | 140,237 | $7.83 | $1.1M | +4.1% | Form 4 ↗ |
| Jul 22, 2026 | ACOG Alpha Cognition Inc. | Buy | 10,000 | $7.83 | $78.3K | +4.1% | Form 4 ↗ |
| Jul 14, 2026 | ETON Eton Pharmaceuticals, Inc. | Sale | 15,000 | $37.54 | $563.1K | +70.1% | Form 4/A ↗ |
| Jul 14, 2026 | ETON Eton Pharmaceuticals, Inc. | Sale | 13,315 | $37.54 | $499.8K | +70.1% | Form 4/A ↗ |
| Jul 14, 2026 | SLGL Sol-Gel Technologies Ltd. | Buy | 920 | $73.43 | $67.6K | -27.2% | Form 4 ↗ |
| Jul 13, 2026 | SLGL Sol-Gel Technologies Ltd. | Buy | 775 | $73.89 | $57.3K | -26.1% | Form 4 ↗ |
| Jul 10, 2026 | SLGL Sol-Gel Technologies Ltd. | Buy | 229 | $73.95 | $16.9K | -25.4% | Form 4 ↗ |
| Jul 8, 2026 | SLGL Sol-Gel Technologies Ltd. | Buy | 300 | $73.69 | $22.1K | -27.5% | Form 4 ↗ |
| Jul 7, 2026 | ETON Eton Pharmaceuticals, Inc. | Sale | 20,000 | $38.37 | $767.4K | +68.5% | Form 4 ↗ |
| Jul 7, 2026 | ETON Eton Pharmaceuticals, Inc. | Sale | 6,685 | $38.37 | $256.5K | +68.5% | Form 4 ↗ |
| Jul 6, 2026 | ETON Eton Pharmaceuticals, Inc. | Sale | 10,000 | $38.00 | $380.0K | +67.7% | Form 4 ↗ |
| Jul 2, 2026 | ETON Eton Pharmaceuticals, Inc. | Sale | 25,000 | $37.39 | $934.8K | +69.2% | Form 4 ↗ |
| Jul 2, 2026 | ETON Eton Pharmaceuticals, Inc. | Sale | 65,000 | $37.39 | $2.4M | +69.2% | Form 4 ↗ |
| Jul 2, 2026 | SLGL Sol-Gel Technologies Ltd. | Buy | 1,400 | $71.97 | $100.8K | -26.8% | Form 4 ↗ |
| Jul 1, 2026 | SLGL Sol-Gel Technologies Ltd. | Buy | 312 | $71.99 | $22.5K | -24.6% | Form 4 ↗ |
| Jun 26, 2026 | ACOG Alpha Cognition Inc. | Buy | 152,336 | $6.40 | $975.0K | +24.2% | Form 4 ↗ |
| Jun 25, 2026 | ACOG Alpha Cognition Inc. | Buy | 197 | $6.50 | $1,281 | +25.0% | Form 4 ↗ |
| Jun 15, 2026 | ACOG Alpha Cognition Inc. | Buy | 4,550 | $5.99 | $27.3K | +38.6% | Form 4 ↗ |
| Jun 12, 2026 | ACOG Alpha Cognition Inc. | Buy | 273 | $5.93 | $1,619 | +36.9% | Form 4 ↗ |
| Jun 11, 2026 | ACOG Alpha Cognition Inc. | Buy | 2,862 | $5.91 | $16.9K | +35.2% | Form 4 ↗ |
| Jun 10, 2026 | ACOG Alpha Cognition Inc. | Buy | 5,872 | $5.99 | $35.2K | +34.6% | Form 4 ↗ |
| Jun 9, 2026 | ACOG Alpha Cognition Inc. | Buy | 24,856 | $5.98 | $148.6K | +36.0% | Form 4 ↗ |
| Jun 5, 2026 | ACOG Alpha Cognition Inc. | Buy | 10,054 | $5.83 | $58.6K | +40.3% | Form 4 ↗ |
| May 29, 2026 | ACOG Alpha Cognition Inc. | Buy | 70,577 | $5.90 | $416.4K | +34.4% | Form 4 ↗ |
| May 28, 2026 | ACOG Alpha Cognition Inc. | Buy | 2,000 | $5.83 | $11.7K | +39.8% | Form 4 ↗ |
| May 27, 2026 | ACOG Alpha Cognition Inc. | Buy | 1,161 | $5.73 | $6,653 | +44.3% | Form 4 ↗ |
| May 21, 2026 | ACOG Alpha Cognition Inc. | Buy | 15,945 | $5.70 | $90.9K | +41.0% | Form 4 ↗ |
| May 20, 2026 | ACOG Alpha Cognition Inc. | Buy | 8,431 | $5.89 | $49.7K | +39.1% | Form 4 ↗ |
| May 20, 2026 | SLGL Sol-Gel Technologies Ltd. | Buy | 1,563 | $64.43 | $100.7K | -17.3% | Form 4 ↗ |
| May 18, 2026 | ACOG Alpha Cognition Inc. | Buy | 17,395 | $5.69 | $99.0K | +42.2% | Form 4 ↗ |
| May 15, 2026 | ACOG Alpha Cognition Inc. | Buy | 16,648 | $5.83 | $97.1K | +35.8% | Form 4 ↗ |
| May 13, 2026 | SLGL Sol-Gel Technologies Ltd. | Buy | 1,937 | $66.87 | $129.5K | -26.2% | Form 4 ↗ |
| May 12, 2026 | SLGL Sol-Gel Technologies Ltd. | Buy | 1,500 | $67.98 | $102.0K | -20.2% | Form 4 ↗ |
| May 1, 2026 | SNWV SANUWAVE Health, Inc. | Sale | 10,081 | $16.11 | $162.4K | -93.1% | Form 4 ↗ |
| May 1, 2026 | SNWV SANUWAVE Health, Inc. | Sale | 500 | $16.11 | $8,055 | -93.1% | Form 4 ↗ |
| Apr 30, 2026 | SNWV SANUWAVE Health, Inc. | Sale | 24,000 | $16.15 | $387.6K | -93.9% | Form 4 ↗ |
| Apr 30, 2026 | SNWV SANUWAVE Health, Inc. | Sale | 1,000 | $16.15 | $16.1K | -93.9% | Form 4 ↗ |
| Apr 29, 2026 | SNWV SANUWAVE Health, Inc. | Sale | 1,000 | $17.25 | $17.3K | -95.1% | Form 4 ↗ |
| Apr 29, 2026 | SNWV SANUWAVE Health, Inc. | Sale | 23,360 | $17.25 | $403.0K | -95.1% | Form 4 ↗ |
| Apr 28, 2026 | SNWV SANUWAVE Health, Inc. | Sale | 2,500 | $18.47 | $46.2K | -96.1% | Form 4 ↗ |
| Apr 28, 2026 | SNWV SANUWAVE Health, Inc. | Sale | 43,788 | $18.47 | $808.8K | -96.1% | Form 4 ↗ |
| Apr 21, 2026 | SNWV SANUWAVE Health, Inc. | Sale | 202 | $20.50 | $4,141 | -97.7% | Form 4 ↗ |
| Apr 17, 2026 | SNWV SANUWAVE Health, Inc. | Sale | 11,267 | $20.46 | $230.5K | -97.4% | Form 4 ↗ |
| Apr 17, 2026 | SNWV SANUWAVE Health, Inc. | Sale | 5,000 | $20.46 | $102.3K | -97.4% | Form 4 ↗ |
| Mar 30, 2026 | ACOG Alpha Cognition Inc. | Buy | 1,850 | $4.99 | $9,232 | +36.6% | Form 4 ↗ |
| Mar 27, 2026 | ACOG Alpha Cognition Inc. | Buy | 10,000 | $5.08 | $50.8K | +44.4% | Form 4 ↗ |
| Mar 26, 2026 | ACOG Alpha Cognition Inc. | Buy | 7,319 | $5.28 | $38.6K | +38.5% | Form 4 ↗ |
| Mar 25, 2026 | ACOG Alpha Cognition Inc. | Buy | 8,581 | $5.43 | $46.6K | +41.2% | Form 4 ↗ |
| Mar 24, 2026 | ACOG Alpha Cognition Inc. | Buy | 4,182 | $5.59 | $23.4K | +33.0% | Form 4 ↗ |
| Mar 24, 2026 | SLGL Sol-Gel Technologies Ltd. | Buy | 34,665 | $72.00 | $2.5M | -46.6% | Form 4 ↗ |
| Mar 24, 2026 | SLGL Sol-Gel Technologies Ltd. | Buy | 5,000 | $72.00 | $360.0K | -46.6% | Form 4 ↗ |
| Mar 19, 2026 | ACOG Alpha Cognition Inc. | Buy | 2,094 | $5.71 | $12.0K | +27.8% | Form 4 ↗ |
| Mar 18, 2026 | ACOG Alpha Cognition Inc. | Buy | 2,481 | $5.75 | $14.3K | +30.3% | Form 4 ↗ |
| Mar 16, 2026 | ACOG Alpha Cognition Inc. | Buy | 1,331 | $5.78 | $7,693 | +30.6% | Form 4 ↗ |
| Mar 13, 2026 | ACOG Alpha Cognition Inc. | Buy | 7,358 | $5.75 | $42.3K | +30.4% | Form 4 ↗ |
| Mar 12, 2026 | ACOG Alpha Cognition Inc. | Buy | 5,708 | $5.85 | $33.4K | +28.6% | Form 4 ↗ |
| Mar 9, 2026 | ACOG Alpha Cognition Inc. | Buy | 2,179 | $5.85 | $12.7K | +30.2% | Form 4 ↗ |
Each row links to its Form 4. Since trade compares the stock’s move from the close on the trade date (or the next trading day) to its latest close with the S&P 500 over the same days, adjusted for splits and excluding dividends. It describes the stock, not what the trader made: we don’t know their purchase price, position size or later sales. A dash means the trade isn’t matched to a listed stock, or there is no closing price after it yet.
When several people report on the same filing, we list it under the first one named, so trades by someone usually listed second may be missing here. Information, not investment advice: see the disclaimer.